Gene interactions - Genes don't work in isolation, and your gene lists shouldn't either
Genes don't work in isolation, and your gene lists shouldn't either. Researchers will often have a list of known genes to look for when prioritizing variants based on the patient's clinical diagnosis. but what should you do if no candidate variants can be found solely based on your gene list? There are many approaches, but one option is to expand the gene list based on known gene interactions and pathways. We rely on the highly curated database called BioGRID to expand the gene list to include the network of genes known to interact either directly or through protein-to-protein interactions. To use this new feature, there is a new checkbox called 'Gene interactions' which users can tick to expand their gene-based search in this way.